circRNA basic information
circBase ID: hsa_circ_0078465
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr6:158850767-158882761:+
Genomic location(hg38): chr6:158429735-158461729:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung adenocarcinoma tissue; adjacent normal tissue
Cell lines:

NCI-H1975; HCC827; NCI-H1975/OSIR; HCC827/OSIR; BEAS-2B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NRAS
Associated microRNA: miR-183-5p
Biological function: Promotes proliferation, migration, and invasion in osimertinib-resistant lung adenocarcinoma cells and is involved in osimertinib resistance.
Molecular mechanism: hsa_circ_0078465 acts in a ceRNA axis with miR-183-5p and NRAS; hsa_circ_0078465 binds miR-183-5p and modulates NRAS in osimertinib-resistant lung adenocarcinoma cells.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); drug resistance (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down
Clinical significance:

-
Description:

hsa_circ_0078465 is upregulated in lung adenocarcinoma and further upregulated in osimertinib-resistant lung adenocarcinoma cells. The study validates a hsa_circ_0078465/miR-183-5p/NRAS ceRNA axis that promotes proliferation, migration, invasion, and osimertinib resistance in LUAD cells.
Confidence score:

0.642
Other information
Title:

Identifying circRNA-miRNA-mRNA Networks Associated with Osimertinib Resistance in Lung Adenocarcinoma by Analyzing Microarray Datasets.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
Published: 2025
PubMed ID: 40493902
Study type:

combined biological and bioinformatics study
Data availability: GSE146689; GSE161348; GSE263003; GSE244311; ENCORI/starBase; Circular RNA Interactome; TargetScan
Code availability: -