| Expression pattern: |
UP |
| Associated gene: |
MYH9 |
| Associated microRNA: |
miR-335-5p |
| Biological function: |
Promotes osteosarcoma cell proliferation, glycolysis, migration, and invasion; accelerates tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-335-5p to upregulate MYH9. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; MTT; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
High circATP2A2 expression was associated with shorter overall survival; serum circATP2A2 showed diagnostic value with AUC=0.77. |
| Description: |
circATP2A2 is upregulated in osteosarcoma tissues/cells and patient serum and mainly localizes to the cytoplasm. It promotes osteosarcoma malignant behaviors and glycolysis by sponging miR-335-5p to upregulate MYH9, and its high expression indicates worse overall survival and has diagnostic potential. |
| Confidence score: |
0.8621 |