circRNA basic information
circBase ID: hsa_circ_0001785
Name: -
Synonym: circ_0001785
Host Gene: -
Genomic location(hg19): chr8:28013458-28019595:+
Genomic location(hg38): chr8:28155941-28162078:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues
Cell lines:

T47D; MCF-7; MDA-MB-453; MDA-MB-231; BT-549; MCF-10A
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: SOCS3, Ago2
Associated microRNA: miR-942
Biological function: Inhibits breast cancer cell proliferation, migration and invasion in vitro, and suppresses tumor growth in vivo.
Molecular mechanism: Acts as a ceRNA that sponges miR-942 to upregulate SOCS3 expression.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

Potential biomarker for early diagnosis and therapeutic target for breast cancer.
Description:

hsa_circ_0001785 is down-regulated in breast cancer cells. Its overexpression suppresses breast cancer cell proliferation, migration, invasion, and xenograft tumor growth by acting as a ceRNA for miR-942, thereby upregulating SOCS3. The study proposes circ_0001785 as a potential biomarker and therapeutic target for breast cancer.
Confidence score:

0.6276
Other information
Title:

Circular RNA hsa_circ_0001785 inhibits the proliferation, migration and invasion of breast cancer cells in vitro and in vivo by sponging miR-942 to upregulate SOCS3.

Journal: Cell cycle (Georgetown, Tex.)
Published: 2020
PubMed ID: 33054543
Study type:

biological research
Data availability: The datasets used or analysed during the current study are available from the corresponding author on reasonable request.
Code availability: -