circRNA basic information
circBase ID: hsa_circ_0032704
Name: hsa_circ_TTLL5
Synonym: -
Host Gene: TTLL5
Genomic location(hg19): chr14:76173360-76187046:+
Genomic location(hg38): chr14:75707017-75720703:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; paired non-tumor liver tissues
Cell lines:

HepG2; L02
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1248, hsa-miR-1236-3p, hsa-miR-203a-3p
Biological function: may promote HCC progression (predicted)
Molecular mechanism: predicted miRNA sponge targeting miR-203a
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Sanger Sequencing; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0032704 is up-regulated in HCC and validated in HepG2 vs L02. The paper suggests it may act as a miRNA sponge (predicted) for miR-203a, potentially promoting HCC progression by relieving repression of oncogenic targets.
Confidence score:

0.5135
Other information
Title:

Circular RNA Signature in Hepatocellular Carcinoma.

Journal: Journal of Cancer
Published: 2019
PubMed ID: 31293639
Study type:

combined biological and bioinformatics study
Data availability: GSE94508; GSE97332
Code availability: -