| Expression pattern: |
DN |
| Associated gene: |
FAM96A |
| Associated microRNA: |
let-7f-5p |
| Biological function: |
Inhibits proliferation, migration, and invasion of lung adenocarcinoma cells (tumor suppressor role). |
| Molecular mechanism: |
Acts as a miRNA sponge for let-7f-5p to positively regulate FAM96A expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Bioinformatics Analysis; Luciferase Reporter Assay; Western Blot; Transfection; CCK8; Transwell Assay; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
hsa_circ_0000018 is down-regulated in lung adenocarcinoma and functions as a tumor suppressor in vitro. It sponges let-7f-5p to relieve repression on FAM96A, thereby inhibiting proliferation, migration, and invasion of LA cells. |
| Confidence score: |
0.7129 |