| Expression pattern: |
UP |
| Associated gene: |
AFP, PTEN, PI3K/Akt pathway |
| Associated microRNA: |
miR-1236-3p |
| Biological function: |
Oncogenic properties in HCC; may promote HCC progression by sequestering miR-1236-3p (bioinformatics-supported). |
| Molecular mechanism: |
Bioinformatically predicted ceRNA/miRNA sponge mechanism involving miR-1236-3p and downstream AFP/PTEN/PI3K/Akt; not experimentally validated here. |
| Biological pathway or process: |
ceRNA regulation (other); PI3K/AKT (other) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Plasma biomarker for HCC diagnosis (AUC = 0.80) and for distinguishing metastatic vs non-metastatic HCC (AUC = 0.72); positively correlates with tumor size, AFP and disease severity. |
| Description: |
Plasma circ_0027478 is significantly up-regulated in HCC and has moderate diagnostic/prognostic value, including distinguishing metastatic from non-metastatic cases. Bioinformatics suggests it is cytoplasmic and may act as a miRNA sponge for miR-1236-3p, potentially impacting the AFP/PTEN/PI3K-Akt axis, but this mechanism was not experimentally validated in the study. |
| Confidence score: |
0.559 |