| Expression pattern: |
UP |
| Associated gene: |
alpha-synuclein (a-syn), P53 |
| Associated microRNA: |
- |
| Biological function: |
May be pathologically associated with alpha-synuclein aggregation, affect biological processes and actin backbone stability, and serve as a rehabilitation-responsive biomarker in PD. |
| Molecular mechanism: |
Predicted epigenetic mechanism involving alpha-synuclein aggregation, regulation of small GTPase-mediated signal transduction, and possible P53 pathway activation. |
| Biological pathway or process: |
p53 signaling (promotes); other pathway/process (promotes); mitochondrial function (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential diagnostic target and rehabilitation-responsive biomarker for PD. |
| Description: |
hsa_circ_0001535/circFAM13B is up-regulated in peripheral blood exosomes from PD patients and decreases after rehabilitation. The study proposes that it may be linked to alpha-synuclein aggregation, actin backbone stability, small GTPase-mediated signaling, and P53-related pathological processes, making it a potential biomarker and rehabilitation target. |
| Confidence score: |
0.4032 |