| Expression pattern: |
UP |
| Associated gene: |
SPIN1, Argonaute 2 (Ago2) |
| Associated microRNA: |
miR-375 |
| Biological function: |
circ_0086720 knockdown strengthens radiosensitivity of NSCLC cells, inhibits cell survival and colony formation, induces apoptosis, and blocks tumor growth in vivo. |
| Molecular mechanism: |
circ_0086720 functions as a competing endogenous RNA targeting miR-375, thereby regulating SPIN1 expression and NSCLC radioresistance. |
| Biological pathway or process: |
radioresistance (promotes); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model |
| Clinical significance: |
circ_0086720 is highly expressed in radioresistant NSCLC tissues and might be used as an indicator of NSCLC radiotherapy. |
| Description: |
circ_0086720 is up-regulated in NSCLC and particularly in radioresistant NSCLC tissues. Its knockdown increases NSCLC radiosensitivity by reducing cell survival and tumor growth and inducing apoptosis. Mechanistically, circ_0086720 acts through the miR-375/SPIN1 axis, consistent with a ceRNA-type regulatory mechanism. |
| Confidence score: |
0.7277 |