| Expression pattern: |
UP |
| Associated gene: |
MAPK1 |
| Associated microRNA: |
miR-326 |
| Biological function: |
promotes prostate cancer cell viability, proliferation, colony formation, migration and invasion |
| Molecular mechanism: |
ceRNA mechanism: circSLC19A1 sponges miR-326 to increase MAPK1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Pearson correlation analysis; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Clinical Sample Validation |
| Clinical significance: |
High circSLC19A1 expression was associated with higher clinical T stage and metastasis (lymph node and distant metastasis). |
| Description: |
circSLC19A1 is up-regulated in prostate cancer tissues and cell lines and acts as an oncogenic circRNA. Its knockdown suppresses PCa cell proliferation/colony formation, migration and invasion by sponging miR-326 and thereby reducing MAPK1 expression (circSLC19A1/miR-326/MAPK1 ceRNA axis). |
| Confidence score: |
0.7846 |