| Expression pattern: |
UP |
| Associated gene: |
ARID5B, RUNX1 |
| Associated microRNA: |
miR-370-3p |
| Biological function: |
promotes cell survival and proliferation; inhibits apoptosis |
| Molecular mechanism: |
putative miRNA sponge activity inferred from predicted binding sites |
| Biological pathway or process: |
apoptosis (inhibits); proliferation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; divergent primers PCR; Transfection; Annexin V/PI Flow Cytometry; EdU Staining; Bioinformatics Analysis; Clinical Sample Validation; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circNR3C1 is upregulated in KMT2A::AFF1 BCP-ALL and functions as an oncogenic circRNA in vitro. Silencing increases apoptosis and reduces proliferation, and bioinformatic predictions suggest it may act through miRNA-binding and downstream target-gene regulation. |
| Confidence score: |
0.725 |