| Expression pattern: |
DN |
| Associated gene: |
NPTX1 |
| Associated microRNA: |
miR-182 |
| Biological function: |
Suppresses HCC cell proliferation and invasion in vitro and reduces tumor growth in vivo; acts as a tumor suppressor in HCC progression. |
| Molecular mechanism: |
hsa_circ_0070269 functions as a ceRNA/miRNA sponge for miR-182, increasing NPTX1 expression and thereby suppressing HCC progression. |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
Low hsa_circ_0070269 expression is associated with advanced TNM stage, large tumor size, lymph node metastasis, and poor overall survival/prognosis; hsa_circ_0070269 may serve as a potential therapeutic target for HCC treatment. |
| Description: |
hsa_circ_0070269 is down-regulated in HCC tissues and cell lines, and low expression is associated with aggressive clinicopathological features and poor prognosis. Functionally, hsa_circ_0070269 suppresses HCC proliferation, invasion, and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic miR-182 sponge to increase NPTX1 expression, forming a hsa_circ_0070269/miR-182/NPTX1 tumor-suppressive axis. |
| Confidence score: |
0.7855 |