circRNA basic information
circBase ID: -
Name: hsa_circ_DDX17
Synonym: Circular RNA DDX17 / circDDX17
Host Gene: DDX17
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006373
MONDO name: pituitary gland adenoma
Disease details: pituitary adenomas
Disease DO ID:
 3829
Disease MeSH ID:
 -
Disease NCIt ID:
 C3329
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PA tissues; normal pituitary tissues
Cell lines:

HP75
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: CADM2, AGO2, MMP2, MMP9
Associated microRNA: miR-1279
Biological function: Inhibits migration and invasion; inhibits proliferation; suppresses tumor growth and invasion in vivo
Molecular mechanism: Acts as a miRNA sponge for miR-1279 to upregulate CADM2, affecting invasion-related proteins (MMP2/9)
Biological pathway or process:

migration (inhibits); invasion (inhibits); proliferation (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining
Clinical significance:

circDDX17 levels could act as a valuable biomarker to distinguish patients with PA from healthy controls (AUC 0.9632); low circDDX17 correlated with poor progression-free survival (PFS)
Description:

circDDX17 is down-regulated in pituitary adenomas and acts as a tumor suppressor by inhibiting PA cell migration, invasion, and proliferation. Mechanistically, it sponges miR-1279 to de-repress CADM2, influencing invasion-associated proteins such as MMP2/9, and it suppresses xenograft tumor growth and invasion. Clinically, higher circDDX17 is associated with better PFS and shows diagnostic potential by ROC analysis.
Confidence score:

0.8229
Other information
Title:

CircDDX17 inhibits invasive progression of pituitary adenomas by sponging miR-1279 and regulating CADM2 expression.

Journal: Frontiers in oncology
Published: 2023
PubMed ID: 38023219
Study type:

combined biological and clinical study
Data availability: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Code availability: -