| Expression pattern: |
DN |
| Associated gene: |
SPI1 |
| Associated microRNA: |
hsa-miR-569 |
| Biological function: |
CircPDE4D acts as a tumor suppressor in CRC; its silencing promotes proliferation, migration and invasion and inhibits apoptosis, while its overexpression inhibits proliferation and migration and induces apoptosis, including in oxaliplatin-resistant CRC cells. |
| Molecular mechanism: |
CircPDE4D may function as a ceRNA that negatively regulates hsa-miR-569 and modulates SPI1 expression in CRC and oxaliplatin-resistant CRC cells. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other); chemoresistance (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; TUNEL; Bioinformatics Analysis |
| Clinical significance: |
CircPDE4D may provide a promising therapeutic target for CRC, especially chemoresistant CRC. |
| Description: |
CircPDE4D is a PDE4D-derived human circRNA that is downregulated in CRC cells and tissues. It functions as a tumor suppressor by inhibiting CRC cell proliferation, migration and invasion and promoting apoptosis, and it also suppresses malignant phenotypes in oxaliplatin-resistant CRC cells. Mechanistically, the study suggests that circPDE4D may regulate the hsa-miR-569/SPI1 axis and may serve as a therapeutic target for CRC and chemoresistant CRC. |
| Confidence score: |
0.6903 |