circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA2499
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

AGS; HGC27
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potentially involved in cell cycle, apoptosis, and cell-substrate adhesion in berberine-treated gastric cancer cells (predicted by enrichment analysis).
Molecular mechanism: Assumed to act as a miRNA sponge in a predicted circRNA-miRNA-mRNA network.
Biological pathway or process:

cell cycle (other); apoptosis (other); ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

circRNA2499 was identified as a berberine-responsive circRNA that is up-regulated in AGS and HGC27 gastric cancer cells after berberine treatment. The study predicts that it may function as a miRNA sponge within a circRNA-miRNA-mRNA network, with target-gene enrichment suggesting involvement in cell-cycle-related processes (e.g., mitotic prometaphase).
Confidence score:

0.2465
Other information
Title:

Effects of Berberine on Circular RNA Expression Profiles in Human Gastric Cancer Cells.

Journal: Evidence-based complementary and alternative medicine : eCAM
Published: 2021
PubMed ID: 34055022
Study type:

biological research
Data availability: The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -