| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-620 |
| Biological function: |
Suppresses HCC cell proliferation, colony formation, migration and invasion; inhibits the tumourigenicity of HCC. |
| Molecular mechanism: |
hsa_circ_103809 acts as a miR-620 sponge, binds miR-620 and negatively regulates miR-620 expression to suppress HCC proliferation and invasion. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Nuclear-Cytoplasmic Fractionation |
| Clinical significance: |
hsa_circ_103809 may serve as a potential biomarker and therapeutic target for HCC; its expression was related to tumour size, invasion, lymph node metastasis, distal metastasis and TNM stage. |
| Description: |
hsa_circ_103809 is a ZFR-derived human circRNA that is down-regulated in HCC tissues and cell lines. It mainly localizes in the cytoplasm and suppresses HCC cell proliferation, colony formation, migration and invasion by binding to and down-regulating miR-620. Its reduced expression is associated with aggressive clinicopathological features, suggesting biomarker and therapeutic potential in HCC. |
| Confidence score: |
0.7884 |