| Expression pattern: |
DN |
| Associated gene: |
AR, HIAT1, CDC42 |
| Associated microRNA: |
miR-195-5p, miR-29a-3p, miR-29c-3p |
| Biological function: |
circHIAT1 functions as a metastatic inhibitor that suppresses AR-enhanced ccRCC cell migration, invasion and metastasis; lower circHIAT1 expression is associated with metastatic ccRCC and worse overall survival. |
| Molecular mechanism: |
AR suppresses circHIAT1 expression through transcriptional regulation of the host gene HIAT1; circHIAT1 directly interacts with and stabilizes miR-195-5p/miR-29a-3p/miR-29c-3p, which target CDC42 to suppress ccRCC migration and invasion. |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; RNA Pull-Down; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; ChIP / ChIP-seq; Transfection; Western Blot; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Lower circHIAT1 expression is associated with metastatic ccRCC and worse overall survival; circHIAT1 may be a potential biomarker and therapeutic target for ccRCC. |
| Description: |
circHIAT1 is down-regulated in ccRCC and is further lower in metastatic disease. AR represses circHIAT1 by transcriptionally regulating the HIAT1 host gene, and reduced circHIAT1 destabilizes miR-195-5p/miR-29a-3p/miR-29c-3p, increasing CDC42 signaling to promote migration, invasion and metastasis. Higher circHIAT1 expression is associated with better overall survival, supporting its role as a metastasis suppressor and potential biomarker/therapeutic target. |
| Confidence score: |
0.859 |