circRNA basic information
circBase ID: hsa_circ_0021603
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33358620-33363232:+
Genomic location(hg38): chr11:33337074-33341686:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue
Cell lines:

MCF-10A; MDA-MB-231; MCF-7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes cell viability, migration and invasion
Molecular mechanism: circHIPK3-based circRNA-miRNA-mRNA ceRNA network (predicted)
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Transwell Assay
Clinical significance:

-
Description:

In BRCA-mutant breast cancer, circHIPK3 (hsa_circ_0021603; host gene HIPK3) is up-regulated in breast cancer cells and promotes cell viability, migration, and invasion. The study also constructed a circHIPK3-centered circRNA-miRNA-mRNA ceRNA network computationally, but did not experimentally validate specific miRNA/mRNA targets for circHIPK3.
Confidence score:

0.3957
Other information
Title:

Development of a circHIPK3-based ceRNA network and identification of mRNA signature in breast cancer patients harboring BRCA mutation.

Journal: PeerJ
Published: 2023
PubMed ID: 37426414
Study type:

combined biological and clinical study
Data availability: OSF.IO/DS6TA; GSE173766
Code availability: -