| Expression pattern: |
UP |
| Associated gene: |
GREM1 |
| Associated microRNA: |
miR-206 |
| Biological function: |
promotes CC cell growth/proliferation and invasion, inhibits apoptosis, and promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA sponging of miR-206 to upregulate GREM1 (circ_0007534/miR-206/GREM1 axis) |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; MTT; BrdU; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model |
| Clinical significance: |
Circ_0007534 expression was associated with tumor size, TNM stages and distant metastasis in cervical cancer. |
| Description: |
Circ_0007534 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-206 to increase GREM1 expression, thereby promoting proliferation/viability and invasion and inhibiting apoptosis, and its knockdown suppresses xenograft tumor growth via the miR-206/GREM1 axis. |
| Confidence score: |
0.6973 |