| Expression pattern: |
UP |
| Associated gene: |
PD-L1 |
| Associated microRNA: |
miR-485-5p |
| Biological function: |
CircFOXK2 promotes NSCLC tumorigenesis, cell proliferation, migration and invasion, and inhibits CD8+ T-cell cytotoxicity, thereby contributing to immune evasion. |
| Molecular mechanism: |
CircFOXK2 functions as a ceRNA by sponging miR-485-5p to upregulate PD-L1, promoting NSCLC tumorigenesis and suppressing CD8+ T-cell cytotoxicity. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); immune regulation (promotes); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; IHC (Immunohistochemistry); Western Blot; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay; RNA Pull-Down; Annexin V/PI Flow Cytometry |
| Clinical significance: |
CircFOXK2 may serve as a possible therapeutic target for NSCLC. |
| Description: |
CircFOXK2 is up-regulated in NSCLC tissues and cells. It promotes tumorigenesis, proliferation, migration, invasion and immune evasion by sponging miR-485-5p and increasing PD-L1 expression, thereby reducing CD8+ T-cell cytotoxicity against NSCLC cells. |
| Confidence score: |
0.8443 |