| Expression pattern: |
DN |
| Associated gene: |
ADCY5, CHRM2, CNR1, LPAR1 |
| Associated microRNA: |
hsa-mir-450b, hsa-mir-582, hsa-mir-577, hsa-mir-217, hsa-mir-31, hsa-mir-182 |
| Biological function: |
hsa_circRNA_0065173 was down-regulated in CRC tissues and may participate in CRC development through a ceRNA network involving miRNAs and hub genes that could serve as potential therapeutic targets. |
| Molecular mechanism: |
Potential ceRNA mechanism: hsa_circRNA_0065173 may regulate ADCY5, CHRM2, CNR1 and LPAR1 by modulating hsa-mir-450b and hsa-mir-582. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
ADCY5, CHRM2, CNR1 and LPAR1 genes regulated in the predicted hsa_circRNA_0065173 network might serve as potentially relevant targets for the treatment of CRC. |
| Description: |
hsa_circRNA_0065173/hsa_circ_0065173 is a human circRNA derived from SETD2 that is significantly down-regulated in CRC tissues. The study proposes that it may function through a ceRNA network involving hsa-mir-450b and hsa-mir-582 to regulate ADCY5, CHRM2, CNR1 and LPAR1, suggesting potential relevance to CRC mechanisms and therapeutic targets. |
| Confidence score: |
0.4032 |