| Expression pattern: |
DS |
| Associated gene: |
VCAM1, VCAN, THBS1 |
| Associated microRNA: |
- |
| Biological function: |
May be involved in COPD-PH pathogenesis and potentially intercellular signal transduction between HPAECs and HPASMCs under hypoxia; related to proliferation, migration and EndMT. |
| Molecular mechanism: |
Potential ceRNA mechanism via predicted circRNA-miRNA-mRNA regulatory network. |
| Biological pathway or process: |
proliferation (other); migration (other); EMT (other); NF-kappaB (other); TGF-beta/SMAD (other); MAPK (other); inflammation (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Potential biomarkers for COPD-PH. |
| Description: |
hsa_circ_0064656 shows abnormal expression in COPD-PH: up-regulated in patient serum but decreases in hypoxic HPAECs while increasing in hypoxic HPASMCs. The study suggests it may participate in COPD-PH through a predicted ceRNA network and processes linked to proliferation, migration and EndMT, with enrichment in NF-kappaB, TGF-beta, MAPK and TNF signaling. |
| Confidence score: |
0.4032 |