circRNA basic information
circBase ID: hsa_circ_0000137
Name: hsa_circ_ASH1L
Synonym: circASH1L
Host Gene: ASH1L
Genomic location(hg19): chr1:155408117-155408859:-
Genomic location(hg38): chr1:155438326-155439068:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004976
MONDO name: amyotrophic lateral sclerosis
Disease details: amyotrophic lateral sclerosis / ALS
Disease DO ID:
 332
Disease MeSH ID:
 D000690
Disease NCIt ID:
 C34373
Disease ICD11 ID:
 1982355687
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

quadriceps; spinal cord
Cell lines:

-
In vivo animal model:

genetically engineered animal model
circRNA-disease information
Expression pattern:
DS
Associated gene: ASH1L
Associated microRNA: -
Biological function: potential biomarker (proposed)
Molecular mechanism: circRNA/host-gene expression correlation (observational)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection
Clinical significance:

circASH1L could be a promising ALS biomarker
Description:

circASH1L is progressively up-regulated in quadriceps across ALS progression in SOD1G93A mice and is proposed as a potential biomarker; its levels correlate with host gene ASH1L expression.
Confidence score:

0.2586
Other information
Title:

Circular RNA expression in ALS is progressively deregulated and tissue-dependent.

Journal: BMC genomics
Published: 2025
PubMed ID: 40596818
Study type:

biological research
Data availability: -
Code availability: -