| Expression pattern: |
UP |
| Associated gene: |
CREB5 |
| Associated microRNA: |
miR-125a |
| Biological function: |
circVAPA knockdown suppresses cell cycle progression, migration, invasion and glycolysis in colorectal cancer cells. |
| Molecular mechanism: |
Acts as a miR-125a sponge to positively regulate CREB5 expression. |
| Biological pathway or process: |
cell cycle (inhibits); migration (inhibits); invasion (inhibits); glycolysis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Cell Cycle Assay; Transwell Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
circVAPA is up-regulated in colorectal cancer tissues and cell lines. Functionally, circVAPA promotes CRC cell cycle progression, migration/invasion and aerobic glycolysis. Mechanistically, circVAPA acts as a ceRNA by sponging miR-125a to increase CREB5 expression (circVAPA/miR-125a/CREB5 axis). |
| Confidence score: |
0.7911 |