| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-17-3p, hsa-miR-143-5p, hsa-miR-150-3p |
| Biological function: |
Indicative of viremic state; predicted to function as an RNA silencing suppressor by sequestering circulating miRNAs (e.g., miRNAs-150) and thereby potentially enhancing HIV-1 propagation. |
| Molecular mechanism: |
Predicted MRE/miRNA sequestration in circRNA-miRNA-mRNA network. |
| Biological pathway or process: |
ceRNA regulation (other); viral replication (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
CircRNA candidate exclusive to viremic patients and undetectable after ART; proposed as viremia-associated biomarker/target candidate. |
| Description: |
circHIPK3 (hsa-HIPK3_0001) was present in all viremic patients and not detectable after ART suppression. The study predicts circHIPK3 participates in competing endogenous circRNA-miRNA-mRNA networks and may sequester miRNAs such as miR-150, potentially facilitating HIV-1 propagation (hypothesis requiring experimental validation). |
| Confidence score: |
0.1768 |