circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: circPVT1
Host Gene: PVT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005252
MONDO name: heart failure
Disease details: ischemic heart failure / IHF
Disease DO ID:
 -
Disease MeSH ID:
 D006333
Disease NCIt ID:
 C50577
Disease ICD11 ID:
 1458683894
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LV tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-30a-5p, hsa-miR-30d-5p
Biological function: unknown
Molecular mechanism: ceRNA network component (predicted circRNA-miRNA-mRNA interactions)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circPVT1 is significantly upregulated in LV tissue from non-end-stage IHF patients and is included as one of the five circRNAs in the IHF ceRNA network. It is computationally linked to miR-30a-5p and miR-30d-5p within the network, but no circPVT1-specific mechanistic experiments were reported.
Confidence score:

0.348
Other information
Title:

circRNA-miRNA-mRNA Deregulated Network in Ischemic Heart Failure Patients.

Journal: Cells
Published: 2023
PubMed ID: 37947656
Study type:

combined biological and clinical study
Data availability: GSE198945
Code availability: -