circRNA basic information
circBase ID: -
Name: hsa_circ_UBAP2
Synonym: -
Host Gene: UBAP2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OS tissues; nearby non-cancerous tissues
Cell lines:

hFOB1.19; U2OS; SaOS2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: YAP1
Associated microRNA: miR-641
Biological function: promotes proliferation and invasion; promotes EMT
Molecular mechanism: ceRNA (miRNA sponge): circUBAP2 sponges miR-641 to relieve miR-641-mediated repression of YAP1, increasing YAP1 expression/translation.
Biological pathway or process:

proliferation (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circUBAP2 is up-regulated in osteosarcoma tissues and cell lines. It promotes osteosarcoma cell proliferation, invasion and EMT by acting as a miR-641 sponge, thereby increasing YAP1 expression.
Confidence score:

0.7129
Other information
Title:

Circular RNA circUBAP2 regulates proliferation and invasion of osteosarcoma cells through miR-641/YAP1 axis.

Journal: Cancer cell international
Published: 2020
PubMed ID: 32528231
Study type:

combined biological and clinical study
Data availability: All data generated or analysed during this study are included in this published article.
Code availability: -