| Expression pattern: |
UP |
| Associated gene: |
MMP2, AGO2, MMP9, E-cadherin, N-cadherin |
| Associated microRNA: |
miR-136-5p |
| Biological function: |
Facilitates migration, invasion, metastasis and malignant progression of HCC; silencing hsa_circ_0000098 inhibits HCC cell migration and invasion. |
| Molecular mechanism: |
hsa_circ_0000098 functions as a ceRNA by sponging miR-136-5p and regulating the downstream target MMP2, thereby promoting HCC migration, invasion and metastasis. |
| Biological pathway or process: |
ceRNA regulation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; Transwell Assay; Western Blot; Cohort Study; Survival Analysis |
| Clinical significance: |
High expression of hsa_circ_0000098 is associated with poor prognosis and is closely related to tumor size, TNM stage, differentiation, and lymph node metastasis. |
| Description: |
hsa_circ_0000098 is up-regulated in HCC tissues and cell lines, and high expression is associated with worse prognosis and aggressive clinicopathological features. Functionally, it promotes HCC cell migration, invasion, metastasis and malignant progression by acting as a cytoplasmic ceRNA that sponges miR-136-5p and regulates MMP2. |
| Confidence score: |
0.814 |