circRNA basic information
circBase ID: -
Name: hsa_circ_PUM1
Synonym: hsa_circ:chr1:31465237-31,479,949
Host Gene: PUM1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006061
MONDO name: cervical artery dissection
Disease details: Cervical artery dissection / CeAD
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May play an important role in CeAD progression leading to stroke (based on differential expression and enrichment/network analyses).
Molecular mechanism: Predicted ceRNA (miRNA sponge) mechanism via circRNA-miRNA-mRNA network (bioinformatics prediction).
Biological pathway or process:

inflammation (other); immune regulation (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker for CeAD.
Description:

This PUM1-derived circRNA is down-regulated in PBMCs of CeAD patients and validated by qRT-PCR. The paper implicates it in CeAD-associated stroke processes based on predicted circRNA-miRNA-mRNA networks and enrichment analyses.
Confidence score:

0.5135
Other information
Title:

Altered expression of circular RNA in patients with cervical artery dissection.

Journal: Frontiers in neurology
Published: 2023
PubMed ID: 37909033
Study type:

combined biological and clinical study
Data availability: -
Code availability: -