| Expression pattern: |
UP |
| Associated gene: |
target genes |
| Associated microRNA: |
hsa-miR-619-3p, hsa-miR-29b-1-5p, hsa-miR-370-3p, hsa-miR-30d-3p, hsa-miR-30a-3p |
| Biological function: |
Most upregulated circRNA in chemoresistant HCT116-R cells compared with parental HCT116-P cells; predicted to bind five miRNAs. |
| Molecular mechanism: |
Predicted miRNA sponge/miRNA binding mechanism based on bioinformatic prediction; no experimental interaction validation reported. |
| Biological pathway or process: |
chemoresistance (promotes); ceRNA regulation (other) |
| Detected method: |
M
|
| Validation methods: |
RNase R Treatment; Microarray; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa circRNA 103306 was reported as the most upregulated circRNA in chemoresistant HCT116-R cells compared with parental HCT116-P cells, based on microarray profiling. The authors predicted five miRNAs that may bind this circRNA, suggesting a possible miRNA-sponge role, but no RT-qPCR or functional validation was reported for this circRNA. |
| Confidence score: |
0.329 |