| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
High tissue expression is independently associated with favorable overall survival (tumor-suppressor-like prognostic association). |
| Molecular mechanism: |
Not directly identified in this study. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; divergent primers PCR; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
High expression of hsa_circ_0003570 is an inversely independent risk factor for overall survival in HBV-HCC (HR 0.437, p=0.009). |
| Description: |
hsa_circ_0003570 is down-regulated in HBV-HCC tumor tissues versus adjacent nontumor tissues. Higher tissue expression is independently associated with longer overall survival, supporting its use as a favorable prognostic biomarker; the study did not experimentally determine the circRNA’s molecular mechanism in this cohort. |
| Confidence score: |
0.5727 |