| Expression pattern: |
UP |
| Associated gene: |
COL4A5 |
| Associated microRNA: |
miR-137 |
| Biological function: |
Promotes proliferation, migration, invasion and EMT, and inhibits apoptosis in gastric cancer cells. |
| Molecular mechanism: |
Acts as a miR-137 sponge to upregulate COL4A5 expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
circ-LDLRAD3 could act as a diagnostic and prognostic marker for GC. |
| Description: |
circ-LDLRAD3 is up-regulated in gastric cancer tissues and cell lines. It promotes malignant phenotypes (proliferation, migration, invasion, EMT) and suppresses apoptosis by sponging miR-137 to relieve repression of COL4A5. |
| Confidence score: |
0.7181 |