circRNA basic information
circBase ID: hsa_circ_0000479
Name: hsa_circ_EPSTI1
Synonym: circEPSTI1
Host Gene: EPSTI1
Genomic location(hg19): chr13:43528083-43544806:-
Genomic location(hg38): chr13:42953947-42970670:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005550
MONDO name: infectious disease
Disease details: Herpesvirus infection
Disease DO ID:
 0050117
Disease MeSH ID:
 D003141
Disease NCIt ID:
 C26726
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

MRC-5; LEC; Akata(-)
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: interferon-stimulated circRNA
Molecular mechanism: not specified
Biological pathway or process:

immune regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circEPSTI1 (hsa_circ_0000479) is an interferon-stimulated circRNA that is consistently upregulated across IFN-beta/IFN-gamma treatment conditions in multiple cell types, and its induction can also be observed in PBMCs after IFN-beta treatment. The study did not define a specific downstream mechanism for circEPSTI1.
Confidence score:

0.4032
Other information
Title:

Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection.

Journal: bioRxiv : the preprint server for biology
Published: 2023
PubMed ID: 37886542
Study type:

combined biological and clinical study
Data availability: Interferon stimulation: SRR25905055, SRR25905049, SRR25905048, SRR25905050, SRR25905054, SRR25905051, SRR25905053, SRR25905052
Code availability: -