circRNA basic information
circBase ID: hsa_circ_0001588
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr6:26204839-26205043:+
Genomic location(hg38): chr6:26204611-26204815:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; adjacent normal tissues
Cell lines:

MCF-7; MDA-MB-231; BT-549; T47D; MCF-10 A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KPNB1
Associated microRNA: miR-525-3p
Biological function: promotes proliferation, migration, invasion and EMT; associated with unfavorable prognosis
Molecular mechanism: ceRNA mechanism; directly binds miR-525-3p and relieves its repression on KPNB1
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes)
Detected method:
Q
S
M
Validation methods:

RT-qPCR; Microarray; MTT; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Survival Analysis; Cohort Study; Clinical Sample Validation; Bioinformatics Analysis; Transfection
Clinical significance:

high expression is associated with advanced TNM staging, lymph node involvement, distant metastasis, lower 5-year survival, and poor prognosis; promising diagnostic marker and therapeutic target
Description:

hsa_circ_0001588 is upregulated in breast cancer and is associated with advanced stage, lymph node involvement, distant metastasis, and poor survival. Functionally, it promotes proliferation, migration, invasion, and EMT by acting as a miR-525-3p sponge to relieve repression of KPNB1, making it a potential prognostic biomarker and therapeutic target.
Confidence score:

0.7878
Other information
Title:

Prognostic value and cellular function of hsa_circ_0001588 in breast cancer.

Journal: Cytotechnology
Published: 2026
PubMed ID: 41953107
Study type:

combined biological and clinical study
Data availability: GSE182471
Code availability: -