circRNA basic information
circBase ID: hsa_circ_0017842
Name: hsa_circ_FAM188A
Synonym: -
Host Gene: FAM188A
Genomic location(hg19): chr10:15820174-15902519:-
Genomic location(hg38): chr10:15778175-15860520:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC samples; corresponding adjacent non-tumor samples; GC tissues; adjacent normal tissues
Cell lines:

AGS; MKN-7; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SPARC
Associated microRNA: miR-1294
Biological function: Promotes malignancy of gastric cancer cells by enhancing proliferation, migration and invasion.
Molecular mechanism: Acts as a competing endogenous RNA that sponges miR-1294 to upregulate SPARC expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Transfection; EdU Staining; Transwell Assay; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

May provide a novel target for GC therapy.
Description:

hsa_circ_0017842 is up-regulated in gastric cancer tissues and cell lines. It promotes GC cell proliferation, migration and invasion by acting as a ceRNA that sponges miR-1294 and upregulates SPARC, suggesting an oncogenic role and potential therapeutic relevance.
Confidence score:

0.7759
Other information
Title:

hsa_circ_0017842 acts as a competing endogenous RNA to enhance the malignancy of gastric cancer.

Journal: Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Published: 2023
PubMed ID: 36994684
Study type:

combined biological and clinical study
Data availability: GSE93541; GSE103236; GSE79973; GEO DataSets; starBase; circInteractome; TargetScan; STRING
Code availability: -