| Expression pattern: |
UP |
| Associated gene: |
PTEN, PI3K, Akt |
| Associated microRNA: |
miR-7 |
| Biological function: |
promotes proliferation, colony formation, migration, invasion and tumor growth; inhibits apoptosis; abrogates the tumor suppressive effect of miR-7 |
| Molecular mechanism: |
ceRNA mechanism via miR-7 sponge activity, antagonizing miR-7-mediated PTEN/PI3K/AKT signaling |
| Biological pathway or process: |
PI3K/AKT (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; MTT; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot |
| Clinical significance: |
High expression of ciRS-7 was linked to poor survival in the testing cohort and validation cohort, and ciRS-7 may act as a prospective prognostic biological marker and a promising therapeutic target for GC. |
| Description: |
ciRS-7 is upregulated in gastric cancer and correlates with advanced clinicopathologic features and poor survival. Functionally, it acts as a miR-7 sponge to relieve miR-7-mediated suppression of PTEN/PI3K/AKT signaling, thereby promoting malignant behaviors such as proliferation, migration, invasion, and tumor growth while reducing apoptosis. |
| Confidence score: |
0.6589 |