| Expression pattern: |
UP |
| Associated gene: |
Twist2 |
| Associated microRNA: |
miR-1236-3p |
| Biological function: |
Promotes HCC cell proliferation and migration/metastasis. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-1236-3p, thereby elevating Twist2 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
Higher circ_0067835 expression is associated with metastasis, larger tumor size, and lower overall survival in HCC patients. |
| Description: |
circ_0067835 is up-regulated in HCC tissues/cell lines and is associated with metastasis, larger tumor size, and poorer overall survival. Functionally, circ_0067835 promotes proliferation and migration/metastasis by sponging miR-1236-3p, which leads to increased Twist2 expression. |
| Confidence score: |
0.7325 |