| Expression pattern: |
DN |
| Associated gene: |
S1PR1, AGO2, TNF-alpha, IL-6, STAT3 |
| Associated microRNA: |
miR-4689 |
| Biological function: |
promotes proliferation; inhibits apoptosis; modulates T-cell activation; inhibits secretion of TNF-alpha and IL-6 |
| Molecular mechanism: |
ceRNA mechanism (miRNA sponge) targeting miR-4689 to regulate S1PR1 expression |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); JAK/STAT (other); inflammation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; ELISA; Bioinformatics Analysis |
| Clinical significance: |
Lower circPTPN22 expression was associated with higher SLEDAI scores, and circPTPN22 may be a potential biomarker for SLE. |
| Description: |
circPTPN22 is down-regulated in PBMCs from SLE patients and is associated with disease activity. In Jurkat T cells, circPTPN22 promotes proliferation and inhibits apoptosis, and suppresses TNF-alpha/IL-6 secretion by acting as a miR-4689 sponge to de-repress S1PR1 (circPTPN22/miR-4689/S1PR1 axis), with links to JAK-STAT-related signaling. |
| Confidence score: |
0.7295 |