| Expression pattern: |
UP |
| Associated gene: |
TGFBR2, Ago2 |
| Associated microRNA: |
miR-1179 |
| Biological function: |
Promotes pancreatic cancer cell proliferation, migration, invasion and gemcitabine resistance; enhances tumor growth in vivo. |
| Molecular mechanism: |
Acts as a competing endogenous RNA (ceRNA) by sponging miR-1179, thereby relieving repression of TGFBR2. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Wound Healing Assay; Transwell Assay; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0087502 expression is associated with worse prognosis/shorter overall survival in pancreatic cancer patients and correlates with higher histological grade, later tumor stage, and lymph node metastasis. |
| Description: |
circ_0087502 is up-regulated in pancreatic cancer tissues/cell lines and is mainly cytoplasmic. It promotes proliferation, migration, invasion and gemcitabine resistance by sponging miR-1179 and de-repressing TGFBR2 (circ_0087502/miR-1179/TGFBR2 ceRNA axis), and high expression is associated with shorter overall survival. |
| Confidence score: |
0.8439 |