| Expression pattern: |
DN |
| Associated gene: |
UQCRC2 |
| Associated microRNA: |
miR-488 |
| Biological function: |
Suppresses gastric cancer cell proliferation, migration/invasion and tumor growth; promotes apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-488 to upregulate UQCRC2 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); invasion (inhibits); migration (inhibits); apoptosis (promotes); metastasis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; TUNEL; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Lower hsa_circ_0000751 levels were inversely proportional to TNM stage, tumor volume, and lymph node metastasis; potential independent diagnostic marker. |
| Description: |
In gastric cancer, hsa_circ_0000751 (circNUFIP2) is down-regulated and functions as a tumor suppressor. It sponges miR-488, relieving repression of UQCRC2 and thereby inhibiting proliferation and invasion/migration while promoting apoptosis, with in vivo xenograft suppression. |
| Confidence score: |
0.8175 |