| Expression pattern: |
UP |
| Associated gene: |
FGF11 |
| Associated microRNA: |
miR-296-3p |
| Biological function: |
promotes proliferation, migration and invasion and inhibits apoptosis in PTC (especially under high iodine exposure) |
| Molecular mechanism: |
ceRNA mechanism: circ_0004851 sponges miR-296-3p to positively regulate FGF11 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
circ_0004851 is up-regulated in high-iodine PTC and mainly localizes to the cytoplasm. It promotes PTC malignant phenotypes by acting as a ceRNA sponge for miR-296-3p, thereby relieving repression of FGF11 and enhancing proliferation/migration/invasion while inhibiting apoptosis, including in a BCPAP-derived xenograft model under high iodine exposure. |
| Confidence score: |
0.7534 |