| Expression pattern: |
UP |
| Associated gene: |
VEGFA, Ago2 |
| Associated microRNA: |
hsa-miR-383-5p |
| Biological function: |
promotes proliferation, migration, invasion, metastasis, and angiogenesis; inhibits apoptosis (when overexpressed/active) |
| Molecular mechanism: |
Acts as a miRNA sponge/ceRNA for miR-383-5p to regulate VEGFA expression; binds miR-383-5p in an Ago2-containing RISC complex |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); angiogenesis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
High circSNX6 expression was associated with worse overall survival and correlated with advanced TNM stage, tumor size, HCV positivity, and metastasis. |
| Description: |
circSNX6 is up-regulated in HCC tissues and cell lines and is associated with worse overall survival. Functionally, circSNX6 promotes HCC proliferation, migration/invasion, metastasis and angiogenesis by sponging miR-383-5p to increase VEGFA expression, and its knockdown induces apoptosis and suppresses tumor growth/metastasis in vivo. |
| Confidence score: |
0.8616 |