| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Associated with liver cancer stemness and poor prognosis; implicated in regulating EMT; did not significantly affect tumor growth in vivo upon overexpression. |
| Molecular mechanism: |
Included in a constructed ceRNA network and clinical correlation analyses, but specific miRNA/mRNA targets for circ-ZEB1 were not reported in the provided text. |
| Biological pathway or process: |
EMT (other); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; In Vivo Animal Model; Western Blot; IHC (Immunohistochemistry) |
| Clinical significance: |
Prognostic marker association: higher expression in HCC tissues and higher levels in poor differentiation; correlated with poor prognosis (stated). |
| Description: |
circ-ZEB1 (hsa_circ_0004907) is enriched in liver CSC-derived exosomes and is up-regulated in HCC tumor tissues versus matched paraneoplastic tissues. It is reported as associated with stemness/poor prognosis and included in a ceRNA network analysis, but in vivo overexpression did not significantly alter xenograft tumor growth in the described experiments. |
| Confidence score: |
0.6616 |