circRNA basic information
circBase ID: hsa_circ_0088036
Name: hsa_circ_SUSD1
Synonym: hsa_circ_104871
Host Gene: SUSD1
Genomic location(hg19): chr9:114840817-114842445:-
Genomic location(hg38): chr9:112078537-112080165:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary NSCLC tissues; adjacent normal lung tissues; lung tissue specimens
Cell lines:

A549; H1299; H1650; PC-9; HBE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: Bcl-3, TGFbeta, Smad3, Bax, Bcl-2, E-cadherin, N-cadherin
Associated microRNA: miR-1343-3p
Biological function: Functions as an oncogene; promotes NSCLC cell proliferation, migration, invasion, EMT progression, and tumor growth in vivo; inhibits apoptosis.
Molecular mechanism: hsa_circ_0088036 acts as a miR-1343-3p sponge, regulates Bcl-3, and activates the TGFbeta/Smad3/EMT signaling pathway.
Biological pathway or process:

TGF-beta/SMAD (promotes); EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; ROC Analysis; Bioinformatics Analysis
Clinical significance:

hsa_circ_0088036 may serve as a diagnostic biomarker and therapeutic target; its expression correlated with tumor size and TNM stage and predicted poor prognosis of NSCLC patients.
Description:

hsa_circ_0088036 is upregulated in NSCLC tissues and cell lines and is associated with tumor size, TNM stage, diagnostic value, and poor prognosis. Functionally, it promotes proliferation, migration, invasion, EMT, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-1343-3p, upregulates Bcl-3, and activates the TGFbeta/Smad3/EMT signaling pathway.
Confidence score:

0.8508
Other information
Title:

Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR-1343-3p/Bcl-3 axis through TGFbeta/Smad3/EMT signaling.

Journal: Molecular carcinogenesis
Published: 2023
PubMed ID: 37132942
Study type:

combined biological and clinical study
Data availability: GSE101684; datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request
Code availability: -