circRNA basic information
circBase ID: hsa_circ_0135571
Name: hsa_circ_NEAT1
Synonym: -
Host Gene: NEAT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001868
MONDO name: primary angle-closure glaucoma
Disease details: primary angle-closure glaucoma
Disease DO ID:
 1405
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood / whole blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NEAT1
Associated microRNA: hsa-miR-4775
Biological function: May contribute to the development of glaucoma by regulating immune cell function via a circRNA-miRNA-mRNA network.
Molecular mechanism: Putative ceRNA mechanism: hsa_circ_0135571 sponges hsa-miR-4775 to regulate NEAT1 expression.
Biological pathway or process:

immune regulation (other); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker in peripheral blood for glaucoma (as part of DEcircRNAs).
Description:

hsa_circ_0135571 is upregulated in peripheral blood from glaucoma patients and is proposed to act as a miRNA sponge (e.g., hsa-miR-4775) to increase NEAT1 expression, potentially contributing to immune-related mechanisms in glaucoma.
Confidence score:

0.4032
Other information
Title:

Differentially expressed circRNAs in peripheral blood samples as potential biomarkers and therapeutic targets for acute angle-closure glaucoma.

Journal: Scientific reports
Published: 2023
PubMed ID: 37805546
Study type:

combined biological and clinical study
Data availability: GSE210783
Code availability: -