| Expression pattern: |
UP |
| Associated gene: |
BPTF, Ago2 |
| Associated microRNA: |
miR-203a |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion, stemness, tumor growth and metastasis; suppresses apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-203a to relieve repression/activate BPTF, thereby activating Notch signaling and promoting stemness and metastasis-related phenotypes. |
| Biological pathway or process: |
Notch (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); stemness (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; TUNEL; Western Blot; IHC (Immunohistochemistry); IF (Immunofluorescence); In Vivo Animal Model; H&E Staining; Clinical Sample Validation |
| Clinical significance: |
Potential predictive or prognostic factor in CRC. |
| Description: |
hsa_circRNA_102051 (TADA2A-derived) is up-regulated in colorectal cancer, particularly metastatic samples, and mainly localizes to the cytoplasm. It promotes proliferation, invasion/migration, stemness, and in vivo tumor growth/metastasis by sponging miR-203a to increase BPTF and activate Notch signaling. |
| Confidence score: |
0.8541 |