| Expression pattern: |
UP |
| Associated gene: |
mTOR pathway, MDR1 |
| Associated microRNA: |
hsa-miR-4520-2-3p, hsa-miR-208b-5p, hsa-miR-4713-5p, hsa-miR-4659a-3p, hsa-miR-4659b-3p |
| Biological function: |
potential diagnostic biomarker of CD; candidate for differentiating CD from UC |
| Molecular mechanism: |
Predicted miRNA sponge with a circRNA-miRNA-mRNA network correlated with mTOR signaling; not experimentally validated. |
| Biological pathway or process: |
mTOR (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Upregulated in PBMCs in CD vs HCs; diagnostic ROC AUC=0.85; higher in CD than UC and may differentiate CD from UC. |
| Description: |
CircRNA_004662 (circ_004662) is up-regulated in PBMCs from Crohn disease patients and shows good diagnostic performance (AUC 0.85). It is higher in CD than in UC and is proposed to function via a predicted ceRNA network by sponging several miRNAs, potentially linking to the mTOR pathway (prediction only). |
| Confidence score: |
0.5047 |