circRNA basic information
circBase ID: hsa_circ_0001821
Name: hsa_circ_PVT1
Synonym: circular PVT1
Host Gene: PVT1
Genomic location(hg19): chr8:128902834-128903244:+
Genomic location(hg38): chr8:127890588-127890998:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SKOV3 / SKOV-3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Rucaparib and MYC inhibitor treatment significantly decreased circPVT1 expression in an ovarian cancer in vitro model, suggesting involvement in drug-response-related anti-tumor effects.
Molecular mechanism: PARP inhibition and MYC inhibition down-regulate circular PVT1 transcripts; the exact downstream pathway was not defined.
Biological pathway or process:

drug resistance (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR
Clinical significance:

-
Description:

This study examined circPVT1 in an ovarian cancer in vitro model and found that rucaparib, a PARP inhibitor, and 10058F4, a MYC inhibitor, significantly reduced circPVT1 expression. The data suggest that down-regulation of circular PVT1 may be part of the anti-tumor effects of PARP and MYC inhibition, although the exact downstream mechanism was not defined.
Confidence score:

0.1155
Other information
Title:

Effect of MYC and PARP Inhibitors in Ovarian Cancer Using an In Vitro Model.

Journal: Anticancer research
Published: 2024
PubMed ID: 38677725
Study type:

combined biological and bioinformatics study
Data availability: TCGA; GTEX; GDC; OncoDB; cBioportal; UALKAN; ROC Plotter; UCSC Xena
Code availability: -