| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circHIPK3 promotes trophoblast cell migration, invasion, and tube formation; circHIPK3 knockdown inhibits trophoblast cell proliferation, while overexpression has no significant effect on proliferation; circHIPK3 has no significant effect on apoptosis. |
| Molecular mechanism: |
The study indicates that circHIPK3 may contribute to preeclampsia by regulating trophoblast behaviors, but the underlying molecular mechanisms were not explored. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); proliferation (promotes); angiogenesis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry |
| Clinical significance: |
circHIPK3 is significantly decreased in placental tissues from patients with preeclampsia compared with healthy pregnancy controls. |
| Description: |
This study found that circHIPK3 is down-regulated in placental tissues from patients with preeclampsia. Functional experiments in HTR-8/SVneo trophoblast cells indicate that circHIPK3 supports migration, invasion, proliferation, and tube formation, suggesting that reduced circHIPK3 may contribute to abnormal trophoblast behavior and preeclampsia pathogenesis. The molecular mechanism was not defined. |
| Confidence score: |
0.6261 |