| Expression pattern: |
DS |
| Associated gene: |
EIF4A3 |
| Associated microRNA: |
- |
| Biological function: |
Circulating diagnostic biomarker component for GC; levels decrease after tumor resection supporting tumor association. |
| Molecular mechanism: |
Not experimentally resolved; discussed potential interaction with RNA binding protein EIF4A3 for most panel circRNAs. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Member of the 8-circRNA serum risk-prediction model for GC diagnosis (validated in independent cohort). |
| Description: |
hsa_circ_0008768 is included in the validated 8-circRNA serum diagnostic panel for gastric cancer developed from tissue discovery and RT-qPCR validation. The panel differentiates GC from controls and shows decreased post-surgery serum levels, indicating tumor-associated circulation signal. |
| Confidence score: |
0.6556 |