| Expression pattern: |
UP |
| Associated gene: |
Raf1 |
| Associated microRNA: |
miR-7-5p / hsa-miR-892a / hsa-miR-329-5p / hsa-miR-204-3p / hsa-miR-449c-5p |
| Biological function: |
promotes Adriamycin resistance and decreases drug sensitivity; knockdown increases sensitivity to ADM |
| Molecular mechanism: |
ceRNA mechanism acting as a miRNA sponge in the circ 0006528-miR-7-5p-Raf1 axis |
| Biological pathway or process: |
drug resistance (promotes); MAPK (promotes); PI3K/AKT (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Transfection; CCK8; Western Blot; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
higher expression in ADM-resistant breast cancer tissues and cell lines; associated with chemotherapy resistance |
| Description: |
This circRNA is upregulated in Adriamycin-resistant breast cancer tissues and cell lines and contributes to chemoresistance. It likely functions as a miRNA sponge in the circ 0006528 / miR-7-5p / Raf1 axis; silencing circ 0006528 increases ADM sensitivity and reduces Raf1 expression. |
| Confidence score: |
0.6676 |