| Expression pattern: |
UP |
| Associated gene: |
STMN1, AGO2 |
| Associated microRNA: |
miR-526b-5p |
| Biological function: |
promotes proliferation and migration and inhibits apoptosis in HCC; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA sponging of miR-526b-5p leading to upregulation of STMN1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Wound Healing Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
hsa_circ_0119412 is upregulated in hepatocellular carcinoma and mainly localizes in the cytoplasm. It promotes HCC cell proliferation and migration and inhibits apoptosis, partly by sponging miR-526b-5p to upregulate STMN1, and it enhances tumor growth in a cell line-derived xenograft model. |
| Confidence score: |
0.7785 |