| Expression pattern: |
DN |
| Associated gene: |
TKFC, MDA5, IKKepsilon, TBK1, IRF3, IFN-I |
| Associated microRNA: |
- |
| Biological function: |
Suppresses glioma malignant phenotypes and tumorigenesis; inhibits glycolysis/Warburg effect and mitochondrial respiration; promotes IFN-I-mediated antitumor immunity (CD8+ T and NK activation). |
| Molecular mechanism: |
circSOBP binds TKFC protein, reduces TKFC protein level, disrupts TKFC-MDA5 interaction, thereby activating MDA5-mediated IKKepsilon/TBK1/IRF3 signaling and IFN-I transcription; simultaneously suppresses glycolysis/Warburg effect via TKFC. |
| Biological pathway or process: |
glycolysis (inhibits); oxidative phosphorylation (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); immune regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
B
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Northern Blot; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; TUNEL; Western Blot; Co-IP; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); IF (Immunofluorescence); ELISA; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circSOBP is downregulated in glioma tissues and in patient serum, suggesting potential use as a glioma biomarker. |
| Description: |
circSOBP is down-regulated in glioma tissues, glioma cell lines, and patient serum. It suppresses glioma proliferation/migration/invasion and glycolysis by binding TKFC, lowering TKFC protein and disrupting TKFC-MDA5 interaction to activate the IKKepsilon/TBK1/IRF3-IFN-I immune signaling, enhancing CD8+ T and NK antitumor responses in vivo. |
| Confidence score: |
0.8941 |