circRNA basic information
circBase ID: hsa_circ_0102533
Name: hsa_circ_PCNX
Synonym: -
Host Gene: PCNX
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; matched adjacent non-tumorous tissues; whole blood
Cell lines:

NHBE; A549; H1299; H1792; SK-MES-1; SPC-A1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Hsa_circ_0102533 acts as an oncogenic circRNA in NSCLC; its knockdown inhibits NSCLC cell proliferation and induces apoptosis.
Molecular mechanism: PCNX-originated hsa_circ_0102533 is involved in PCNX-mediated proliferation and apoptosis in lung cancer cells; microRNA sponge mechanism was not investigated.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry
Clinical significance:

Hsa_circ_0102533 may serve as a blood-based early diagnostic biomarker for NSCLC detection; AUC was 0.744 for NSCLC patients versus healthy subjects, 0.774 for stage I-II NSCLC, and 0.728 for stage III-IV NSCLC.
Description:

Hsa_circ_0102533 is up-regulated in NSCLC tumor tissues, whole blood, and NSCLC cell lines. It promotes NSCLC cell proliferation and suppresses apoptosis in vitro, and its blood expression shows diagnostic potential, especially for early-stage NSCLC.
Confidence score:

0.7472
Other information
Title:

Hsa_circ_0102533 serves as a blood-based biomarker for non-small-cell lung cancer diagnosis and regulates apoptosis in vitro.

Journal: International journal of clinical and experimental pathology
Published: 2018
PubMed ID: 31949836
Study type:

combined biological and clinical study
Data availability: circBase database, http://www.circbase.org/
Code availability: -