circRNA basic information
circBase ID: hsa_circ_0000722
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr16:85667519-85667738:+
Genomic location(hg38): chr16:85633913-85634132:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-324-5p, miR-326, miR-330-5p
Biological function: May participate in the pathogenesis and progress of NSCLC; potential biomarker/therapeutic target.
Molecular mechanism: Predicted miRNA sponge mechanism (in silico) targeting miR-324-5p, miR-326 and miR-330-5p; circRNA-miRNA-mRNA network analysis.
Biological pathway or process:

ceRNA regulation (other); lipid metabolism (other); glycolysis (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker for NSCLC (circulating plasma).
Description:

hsa_circ_0000722 is up-regulated in NSCLC patient plasma and was proposed as a circulating biomarker. Bioinformatic predictions suggest it may act as a miRNA sponge for miR-324-5p/miR-326/miR-330-5p and relate to cancer-associated pathways.
Confidence score:

0.4032
Other information
Title:

Extracellular RNA profiles in non-small cell lung cancer plasma.

Journal: Journal of thoracic disease
Published: 2023
PubMed ID: 37324105
Study type:

combined biological and clinical study
Data availability: PRJNA589238; PRJNA971084
Code availability: -