| Expression pattern: |
DN |
| Associated gene: |
TRIM13 mRNA, TRIM13, p53 |
| Associated microRNA: |
miR-6864-5p |
| Biological function: |
inhibits proliferation, migration and invasion and induces apoptosis, thereby suppressing HCC progression |
| Molecular mechanism: |
circELMOD3 acts as a sponge for miR-6864-5p to increase TRIM13 expression and also directly binds TRIM13 mRNA to enhance its stability, leading to activation of p53-mediated signaling |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes); mRNA stability (promotes); p53 signaling (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); RNA Pull-Down; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
plasma circELMOD3 was a highly sensitive and non-invasive biomarker to distinguish HCC from healthy controls; circELMOD3 expression was correlated with clinicopathological characteristics of HCC patients |
| Description: |
circELMOD3 is down-regulated in HCC tissues and plasma and functions as a tumor suppressor. It sponges miR-6864-5p to increase TRIM13 and also directly binds TRIM13 mRNA to enhance its stability, thereby activating p53 signaling to inhibit HCC progression. |
| Confidence score: |
0.8836 |