| Expression pattern: |
UP |
| Associated gene: |
TLK1 |
| Associated microRNA: |
miR-664b-3p |
| Biological function: |
promotes NSCLC cell proliferation, EMT, immune escape, migration and invasion; inhibits apoptosis |
| Molecular mechanism: |
circ-MBOAT2 acts as a miRNA sponge for miR-664b-3p, thereby promoting TLK1 expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); EMT (promotes); migration (promotes); invasion (promotes); immune regulation (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study |
| Clinical significance: |
Circum-MBOAT2 up-regulation correlated with tumor size, differentiation, TNM stage, and lymph node metastasis in NSCLC. |
| Description: |
Circ-MBOAT2 is up-regulated in NSCLC tissues/cell lines and promotes malignant phenotypes including proliferation, EMT, migration/invasion and immune escape while suppressing apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-664b-3p to increase TLK1 expression, and its knockdown suppresses tumor growth in a xenograft model. |
| Confidence score: |
0.8655 |