circRNA basic information
circBase ID: -
Name: -
Synonym: circR-4225 / circR-4425
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; surrounding normal tissues; peripheral blood
Cell lines:

A549; SPCA1; HEK-293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: EIF4A3, TNFSF11
Associated microRNA: miR-507
Biological function: Promotes LUAD cell proliferation and viability and inhibits apoptosis; its knockdown suppresses proliferation/viability and enhances apoptosis.
Molecular mechanism: EIF4A3 binds circR-4225 precursor mRNA and promotes circR-4225 expression; circR-4225 sponges miR-507, relieving miR-507-mediated repression of TNFSF11.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RIP (RNA Immunoprecipitation); Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; TUNEL; Luciferase Reporter Assay; Western Blot; Survival Analysis; Wound Healing Assay; Transwell Assay
Clinical significance:

Potential molecular target for early diagnosis and treatment of LUAD.
Description:

circR-4225 is up-regulated in LUAD tissues and promotes LUAD cell proliferation/viability while inhibiting apoptosis. Mechanistically, EIF4A3 promotes circR-4225 expression, and circR-4225 sponges miR-507 to up-regulate TNFSF11.
Confidence score:

0.7552
Other information
Title:

Functional elucidation of the EIF4A3-circR-4225-miR-507-TNFSF11 regulatory axis in LUAD and its role in tumor progression.

Journal: Scientific reports
Published: 2024
PubMed ID: 39198460
Study type:

combined biological and clinical study
Data availability: All relevant data are available from the corresponding authors on request.
Code availability: -